Pepsin
The
Natural Protein Digestant Pepsin
is one of the principal protein degrading or proteolytic enzymes in the digestive
system. During the process of digestion, Pepsin acts on the complex dietary protein
and breaks up into peptides and amino acids which can be readily absorbed by the
intestinal lining. Pepsin
enzyme produced in the mucosal lining of the stomach that acts to degrade protein.
Pepsin is one of three principal protein-degrading, or proteolytic, enzymes in
the digestive system , the other two being chymotrypsin and trypsin. The three
enzymes were among the first to be isolated in crystalline form. During the process
of digestion, these enzymes, each of which is particularly effective in severing
links between particular types of amino acids, collaborate to break down dietary
proteins to their components, i.e., peptides and amino acids , which can be readily
absorbed by the intestinal lining. In the laboratory studies pepsin is most efficient
in cleaving bonds involving the aromatic amino acids, phenylalanine, tryptophan,
and tyrosine. Pepsin is synthesized in an inactive form by the stomach lining;
hydrochloric acid, also produced by the gastric mucosa, is necessary to convert
the inactive enzyme and to maintain the optimum acidity (pH 1-3) for pepsin function.
Pepsin and other proteolytic enzymes are used in the laboratory analysis of various
proteins; Pepsin is a gastric protease active at acidic pH, and formed by partial
proteolysis of its inactive zymogens- the pepsinogens. Pepsin
is manufactured from the frozen intestinal mucosa. The processes involve the controlled
activation of glands followed by filtration, purification and finally spray drying
to a fine powder in totally controlled conditions. Pepsin
is a compact spherical molecule having mol wt = 35,500 Daltons. Pepsin
has an excellent digestion power. Pepsin cleaves proteins preferentially
at carboxylic groups of aromatic amino acids such as phenylalanine and tyrosine.
Pepsin
has a very strong fibrinolytic and caseionolytic activity this in combination
with starch degrading enzyme -amylase and lipid degrading enzyme - lipase acts
as very good digestive aid. Therapeutic
Applications: - It
helps in digestive disturbance in general and as a result of impaired production
of gastric juice.
- It
acts as an adjunct in the treatment of anemic conditions, especially during slimming
diet when protein intake increases.
- It
is used as research tool in protein analysis,
- It
is used as digestive Syrup in heart burn, acid indigestion and sour stomach.
- It
is used in Tablets for increasing appetite.
- It
is also used in the preparation of cheese and other protein-containing foods
Indications: - Loss
of appetite/indigestion.
- Disturbance
of protein digestion/ diarrhea
- Used
in the treatment of pepsin secretion deficiency.
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