Papain The
Natural Protein Digestant
Papain is naturally occurring enzyme,
obtained from latex of fruit of PAPAYA (Carica papaya Latex). The enzyme Papain
is obtained by drying papaya latex by suitable method viz; sun drying, tray drying,
spray drying etc. spray drying gives a fine powder, which dissolves easily in
water to provide a solution of high proteolytic activity. The
crude Papain obtained from the crude latex is extracted, filtered, concentrated
and finally spray dried into a very fine & soluble powder. All processing
of Papain is carried out in aseptic conditions to suit for the pharmaceutical
applications. Papain
is a mixture of proteolytic enzymes derived from the juice of the unripe fruit
of the tropical plant Caroica papaya, commonly known as papaya. Papain hydrolyzes
proteins to form oligopeptides and amino acids. Papain also contains the proteolytic
enzyme chymopapain which differs from papain in electrophoretic mobility, solubility
and substrate specificity. The molecular weight of chymopapain is approximately
27,000 daltons. Papain is used as a digestive aid. It is also used as a meat tenderizer.
Papain has putative anti-inflammatory activity. The activity of papain is expressed
in papain units or PU. The assay of papain activity is based on the hydrolysis
of casein. Pancreatin
enzymes have two important functions in the body: digestion of foods and routine
cancer eradication. Pancreatin is a mix of many different enzymes, and those involved
in the digestion of proteins are also used to help eliminate cancers that occur.
Cancer is often a disease of protein metabolism because the pancreatin enzyme
cancer defense mechanism can be overwhelmed by consuming protein rich foods at
inappropriate times or in excessive amounts. The body needs a time span each day
approaching twelve hours or more without protein consumption for its pancreatin
cancer defense mechanism to work optimally. Pancreatin
enzymes can be made ineffective by contact with acids or alcohols. A diet comprised
mostly of refined foods and meats may result in an acidic body chemistry that
depletes these enzymes. Cancer, once established, ensures its survival by continuously
generating acid as it inefficiently metabolizes food. Consuming alcoholic beverages
can also interfere with the defense mechanism. Many popular cosmetics that contain
acids or alcohols are a special concern for skin cancer. Mercury leakage from
amalgam tooth fillings is also debilitating to many enzyme functions. Mode
of Action: Papain
is a proteolytic (protein degrading) enzyme, characterized by the ability to hydrolyze
large proteins into smaller peptides and amino acids. Its broad substrate specificity
and ability to hydrolyze small peptides as well as large proteins make Papain
an ideal enzymatic supplement. Papain
has a mild, soothing effect on the stomach and is and excellent aid in protein
digestion. Therapeutic
Applications: - Papain
is used as effective digestive aid.
- Papain
helps in digestion of protein in the diet.
- This
digestive activity has been used in cases of gastric discomfort where a sense
of fullness, pain or nausea may be present after meals.
- Papain
is widely used for replacement therapy in pathological conditions in which the
concentration of bile acids in upper intestine is low such as biliary fistula,
disease of the ileum, and hepatic or extra - hepatic cholestasis.
- Papain
is an excellent fibrinolytic and caseionolytic enzyme, which in combination with
amylase and lipase proves to be formidable digestive aid.
- Papain
may be administered in acid solution to increase the digestive power of gastric
juices, particularly where there is a deficiency of pepsin secretions.
- Papain
is used as a debriding agent for cleaning of necrotic wounds, ulcers, sinuses
and fistulas.
- Papain
also finds application as an anti -inflammatory agent in the treatment of bronchial
asthma, bronchitis and thrombophlebitis.
- Papain
can be used as meat tenderizer.
- Papain
is useful in juice and wine clarification

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