Ox
Bile Extract
The natural fat digestant BILE
is a secretion of liver, stored in the gall bladder until needed. Bile has a major
role to play in fat digestion and absorption. The active constituents of bile
are the bile salts, which are either glycine or taurine conjugates of polyhydroxy
steroidal acid. Principal bile acids of mammals are the hydroxyl derivatives of
5 - beta-cholan-24 oic - acid. Ox-bile is the most important commercial
source of these acids and contains primarily Cholic acid with less amount of deoxycholic
acid. Ox
Bile Extract is obtained by mixing fresh Ox Bile paste with solvent. The solvent
mixture is filtered to remove the insoluble material. The solvent is removed by
filtration. The Ox Bile Extract is dried to remove solvent and packed in
bulk packing. Structure
of Ox Bile Extract 
Physiological
Role : Since
dietary fat cannot be dissolved in water, a special type of system is designed
in our body for its digestion and its absorption through the intestinal wall by
bile salts. Bile
salts are strongly amphilic and with the aid of biliary phospholipids, these are
readily form micelles and emulsify lipids. These are important not only for emulsification
of cholesterol and other lipids on food but also for the emulsification of dietary
lipids. Bile also stimulates the secretion of an enzyme responsible for the breakdown
of fats. Bile
aids in the production of an alkaline reaction in the intestines and is essential
for absorption of fats. Bile emulsifies the fats permitting intestinal and pancreatic
lipases to split the triglycerides into diglycerides and monoglycerides and finally
into free fatty acids and glycerol. Choleretic
action of Bile Extract is attributed to bile acids. Bile
Extract also has an important role to play in the absorption of fat-soluble
vitamins A, D, E & K. As a constituent of intestinal contents, Ox bile
acts as an emulsifying agent, mild catharatic and inhibits certain putrefactive
bacteria. Therapeutic
Applications:
Because of their physiological role in the absorption
of dietary lipids, the bile salts are widely used for replacement therapy,
in pathological conditions in which the concentration of bile acids in upper intestines
is low, such as - Biliary
fistula
- Disease
of the ileum
- Hepatic
or extra hepatic cholestasis.
- To
help lower cholesterol & triglycerides
- A
general aid in fat metabolism.
Indications: - Cirrhosis.
- Hepatitis
& other liver disorders.
| 
