Phytase enzyme produced by submerged Fermentation of Aspergillus spp.
Need of Phytase:
Large amount of research show that phytate or phytic acid in monogastric animal's feeds has a strong anti-nutrition effect the reason being:
Monogastric animals lack phytate degrading enzyme in their digestive tract so they are unable to utilize the phosphorus of phytate;
Because the phosphoric acid group is negatively charged, it can strongly chelate with cations such as Ca2+, Mg2+, Zn2+, Cu2+, Mn2+, Fe2+ and K+ to form insoluble salts therefore influencing the absorption and digestion of these minerals by animals and reducing their bio-availability;
The phosphoric acid group of phytate can also integrate with cation groups on protein, amino acids, starch and lipids in feedstuff to reduce their solubility therefore influencing the digestibility of these nutrients by animals and poultry.
Phosphoric acid can also integrate with protein in animal body such as amylase, pepsin, trypsin and acid phosphorylase to reduce their activity therefore influencing the nutrient utilization of whole diet;
Phytate has a negative effect on vitamin utilization therefore animals fed with feeds of high phytate content often display signs such as off-feed, emaciation, retarded growth and reproduction failure.
Phytate also forms complexes with proteins, digestive enzymes and minerals, and as such is considered to be an anti-nutritional factor. Phytase frees the phosphorus contained in cereals and oilseeds, and by breaking down the phytate structure also achieves the release of other minerals such as calcium and magnesium, as well as proteins and amino acids, which have become bound to the phytate. Thus, by releasing bound phosphorus in feed ingredients of vegetable origin, phytase makes more phosphorus available for bone growth, and reduces the amount excreted into the environment. Use of the enzyme also has the added benefit of helping to conserve natural resources by eliminating the need to supplement feeds with sources of digestible inorganic phosphorus. There are two phytases as classified by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (NC-IUBMB) In consultation with the IUPAC-IUBMB Joint Commission on Biochemical Nomenclature (JCBN):
EC 3.1.3.8
Recommended name:
3-phytase
Systematic name: myo-inositol-hexakisphosphate 3-phosphohydrolase
other name(s): phytase; phytate 3-phosphatase
CAS registry number: 37288-11-2
and
EC 3.1.3.26
Recommended name: 6-phytase
Systematic name: myo-inositol-hexakisphosphate 6-phosphohydrolase
other name(s): phytase; phytate 6-phosphatase
CAS registry number: 9001-89-2 SEB Phytase is 6 Phytase.
Mode of action:
Phytic acid and phytate are main storage form of phosphorus in plants. |