PAPAIN is naturally occurring enzyme, obtained from latex of fruit of PAPAYA (Carica papaya Latex). The enzyme Papain is obtained by drying papaya latex by suitable method viz; sun drying, tray drying, spray drying etc. spray drying gives a fine powder, which dissolves easily in water to provide a solution of high proteolytic activity.

The crude Papain obtained from the crude latex is extracted, filtered, concentrated and finally spray dried into a very fine & soluble powder. All processing of Papain is carried out in aseptic conditions to suit for the pharmaceutical applications.

Papain is a mixture of proteolytic enzymes derived from the juice of the unripe fruit of the tropical plant Caroica papaya, commonly known as papaya. Papain hydrolyzes proteins to form oligopeptides and amino acids. Papain also contains the proteolytic enzyme chymopapain which differs from papain in electrophoretic mobility, solubility and substrate specificity. The molecular weight of chymopapain is approximately 27,000 daltons. Papain is used as a digestive aid. It is also used as a meat tenderizer. Papain has putative anti-inflammatory activity. The activity of papain is expressed in papain units or PU. The assay of papain activity is based on the hydrolysis of casein.

Pancreatin enzymes have two important functions in the body: digestion of foods and routine cancer eradication. Pancreatin is a mix of many different enzymes, and those involved in the digestion of proteins are also used to help eliminate cancers that occur. Cancer is often a disease of protein metabolism because the pancreatin enzyme cancer defense mechanism can be overwhelmed by consuming protein rich foods at inappropriate times or in excessive amounts. The body needs a time span each day approaching twelve hours or more without protein consumption for its pancreatin cancer defense mechanism to work optimally.

Pancreatin enzymes can be made ineffective by contact with acids or alcohols. A diet comprised mostly of refined foods and meats may result in an acidic body chemistry that depletes these enzymes. Cancer, once established, ensures its survival by continuously generating acid as it inefficiently metabolizes food. Consuming alcoholic beverages can also interfere with the defense mechanism. Many popular cosmetics that contain acids or alcohols are a special concern for skin cancer. Mercury leakage from amalgam tooth fillings is also debilitating to many enzyme functions.

Mode of Action:
Papain is a proteolytic (protein degrading) enzyme, characterized by the ability to hydrolyze large proteins into smaller peptides and amino acids. Its broad substrate specificity and ability to hydrolyze small peptides as well as large proteins make Papain an ideal enzymatic supplement.

Papain has a mild, soothing effect on the stomach and is and excellent aid in protein digestion.

Therapeutic Applications:
• Papain is used as effective digestive aid.
• Papain helps in digestion of protein in the diet.
• This digestive activity has been used in cases of gastric discomfort where a sense of fullness, pain or nausea may be   present after meals.
• Papain is widely used for replacement therapy in pathological conditions in which the concentration of bile acids in upper   intestine is low such as biliary fistula, disease of the ileum, and hepatic or extra – hepatic cholestasis.
• Papain is an excellent fibrinolytic and caseionolytic enzyme, which in combination with amylase and lipase proves to be   formidable digestive aid.
• Papain may be administered in acid solution to increase the digestive power of gastric juices, particularly where there is a   deficiency of pepsin secretions.
• Papain is used as a debriding agent for cleaning of necrotic wounds, ulcers, sinuses and fistulas.
• Papain also finds application as an anti–inflammatory agent in the treatment of bronchial asthma, bronchitis
  and thrombophlebitis.
• Papain can be used as meat tenderizer.
• Papain is useful in juice and wine clarification.