Pancreatin is a digestive enzyme that is used to supplement loss of or low levels of digestive enzymes, and is often used in people with cystic fibrosis. It has been claimed to help with food allergies, celiac disease, autoimmune disease, cancer, and weight loss. Pancreatin is also known as pancreatic acid.

Pancreatin is made up of the pancreatic enzymes trypsin, amylase, and lipase. Pancreatin is very similar to another enzyme known as pancrelipase. The primary difference between these two enzymes is that pancrelipase contains more active lipase enzyme than pancreatin. The trypsin found in pancreatin works to hydrolyze proteins to oligopetides, amylsas hydrolizes starches to oligosaccharides and the disaccharide maltose, and lipase hydrolyzes triglycerides to fatty acids and glycerols. What does this mean? Pancreatin is an effective enzyme supplement for replacing missing pancreatic enzymes used in a number of essential body processes. Pancreatin enzymes are primarily helpful in digestion of foods and routine cancer eradication.

Pancreatin is secreted by pancreas. Pancreatin is complex of enzymes, which aids in the digestion of carbohydrates, proteins and fat content of the food in the intestine.

The pancreatin is secreted as pancreatic juice, which play extremely important role in human digestive system. It contains different like amylase (Carbohydrates digestive enzymes), proteases (proteins digestive enzymes) and lipase (Fat digestive enzyme), which hydrolyze food intestinal tract.

Under normal circumstances, the pancreas secretes a sufficient amount of enzyme into the intestine to aid in the digestion process. When the pancreas is not functioning properly or is partially removed surgically, lesser amount of pancreatic digestive enzymes are secreted in this case the pancreatin has to be supplemented orally.

Pancreatin is manufactured from the frozen glands of porcine pancreas. The frozen glands are chopped, minced and further processed to get the Pancreatin of highest grade. The process is optimized to get all the three activities viz. Amylase, Protease and Lipase. In fact Pancreatin is the only enzyme in the body, which helps in digestion of fats in the food.

Therapeutic use:
• Pancreatin is used for treatment of conditions in which the secretion of pancreatic juice is deficient e.g. pancreatitis and    mucoviscidosis.
• Pancreatin administration can significantly reduce the nitrogen and fat content of stool and these parameters can be    monitored as a guide to dosage.
• Since acid and peptic activities in stomach can destroy the Pancreatic enzymes, hence enteric-coated tablets are normally    used.

Pancreatin is widely used in Pharmaceutical industry and hence is available in various grades satisfying pharmacopoeia requirements viz.IP, USP, B.P, E.U and F.I.P specifications. The Pancreatin is available both as powder and enteric coated granules of various strengths.

Suggested Dosage and Administration:
A 500-milligram tablet of pancreatin usually has about 12,500 USP units of trypsin, 12,500 USP units of amylase and 1,000 USP units of lipase.

Indications:
• Replacement therapy to treat conditions associated with exocrine pancreatic insufficiency, including cystic fibrosis, chronic     pancreatitis, pancreatic tumors or pancreatectomy.

• Mal absorption due to insufficient digestion in case of Pancreatin insufficiency, which is indicated by the fat content in the stool

• Pancreatin can be use in Leather Bating According to tradition, bating required the excrement of dogs and pigeons, a fact that did not improve the image of tanning which was considered a stinking and unpleasant activity. Rohm's theory was that these excrements exerted their effect because they contained residual amounts of the animals' digestive enzymes. If this was so, it might be possible to use extracts of the pancreas directly for bating. Such extracts were tried and produced the expected positive results. Naturally, Rohm accepted this as confirmation of the correctness of his theory, but later experiments showed that it was not the animals' enzymes that were active, but rather enzymes of bacteria growing in the intestinal tract.